Can Reishi Mushroom Cure Alzheimer’s Disease? There’s hope

Reishi Mushroom https://unsplash.com/s/photos/reishi

OldmateArt 21/05/2026

There is growing scientific interest in how the medicinal mushroom Reishi, Lingzhi in China, might help with processes involved in Alzheimer’s, but at present there is no good evidence that it prevents, cures, or reliably treats Alzheimer’s disease in humans.

Science has discovered that Reishi mushroom has a chemical capacity to control, if not cure, Alzheimer's disease in the human brain. Researchers discovered Reishi mushroom contains 'biologically active compounds'. These being: beta-glucans, polysaccharides, triterpenes （ganoderic acids）, and antioxidants. Conduct an AI search for more information.

Triterpenes have been used in traditional East Asian medicine for thousands of years.

They’re also found in olive leaves, ginseng, birch bark, some fruits and herbs, and have a range of medicinal anti-inflammatory, antioxidant, and anti-cancer properties (Wikipedia).

It is thought that these substances may metamorphose some of the functions involved in Alzheimer's disease; brain inflammation, oxidative stress, formation of amyloid beta-plaque, tau protein damage （tau is a beneficial brain protein）, and damage to nerve cells. Reviews of laboratory and animal research has suggested that Reishi, and other medicinal mushrooms, may protect nerve cells.

What animal studies show

Lab rats and mice fed Reishi extract have better memories, less inflammation, mitigated oxidation damage, and reduced development of amyloid plaque growth. This was clearly found that Reishi extract fed to Azheimer's disease infected rats resulted in them having better memories and improved learning. Not broad proof, and they are rats not humans. More complex trials on humans are needed.

The important limitation

Most of this promising evidence results from laboratory research using animals, or simple preliminary studies. There are rare major clinical human trials proving benefits, for people with Alzheimer's disease. Alas, reviews of research conclude that 'evidence is still preliminary and insufficient for medical recommendations'.

Safety considerations

Generally, Reishi is sold as a supplement, or a tea, and is usually considered to be acceptably safe for adults, in moderation. But it has been found to cause stomach upsets, dry mouth, dizziness, skin reactions, and, in rare cases, possible liver problems. It has been found to interact with blood thinners, blood pressure medicines, diabetes medications, and immune suppressing drugs. Seniors taking a range of medications need to speak with a GP or pharmacist before regular use of Reishi.

Current medical position

Unfortunately, Alzheimer's disease causes brain damage. Currently, Reishi is not an approved treatment for Alzheimer's disease. It is unwise to replace evidence-based medical care, yet. Some researchers think that it may eventually become a drug that's ancillary to standard medical care, but this has not yet been established.

There's stronger evidence for general lifestyle activities that can reduce dementia risk, these should be used. Suggested measures; physical activity, blood pressure control, Mediterranean/MIND diet, good sleep, hearing correction, social engagement, and diabetes management. Lion's Mane Mushroom is also considered to be useful for memory and cognition retention. OldmateArt's personal Lion's Mane supplement experience has been positive.